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[DOI] [PubMed] [Google Scholar] 55.Sander CS, Chang H, Salzmann S, et al

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This underscores a potential weakness of KOG classes and KOG enrichment analysis: genes are only assigned one KOG class and due to the inherent broadness of the classes, a given designation may not be the most representative of gene function in the organism of interest

The key is not avoiding these medications entirely, but: Using appropriate monitoring Implementing preventive strategies Intervening early when problems arise Addressing metabolic effects while maintaining psychiatric stability Balancing risks and benefits: Untreated or inadequately treated depression carries serious risks: Disability and reduced functioning Lost work and relationships Physical health consequences (inflammation, cardiovascular risk) Suicide For many people, the benefits of effective antidepressant treatment outweigh the metabolic risks particularly when those metabolic risks are monitored and addressed